Job Description

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech, a member of the Roche Group. The Opportunity We are seeking a motivated and experienced Technical Development Principal Scientist to join the Analytical Development Department at Genentech. The successful candidate will work in a highly collaborative team environment to lead and deliver analytical method development, product variant characterization, and control strategies for all stages of protein therapeutic development. Additionally, the successful candidate will serve as an analytical representative on cross-functional project teams collaborating with colleagues in Cell Culture, Purification, Pharm Development, Quality and Regulatory groups. What you will do Develop and optimize chromatography, capillary, mass spectrometry based analytical methods to by hands-on, technical execution in the lab, while providing mentorship to junior personnel (where applicable) Perform physico-chemical characterization of pipeline molecules (largely protein based formats such as antibody drug conjugates and new protein drug modalities) to determine critical quality attributes Develop into Molecule Expert role to assist in define and execute phase appropriate analytical control strategy to enable CMC development activities Author and review technical development documents and relevant sections of HA filings Assist in defining and executing phase appropriate analytical control strategy to enable CMC development timelines. Ensure timely analytical support for bioprocess / formulation development and process validation activities. Maintain timely and accurate lab records consistent with good documentation practices. Serve as a team representative and provide analytical knowledge and expertise to cross-functional teams. Who You Are Ph.D. in Analytical Chemistry, Biochemistry, Chemical Engineering, or related scientific discipline plus a minimum of 3+ years analytical development experience for protein therapeutics in the biotech / biopharma industry; or BS / MS with a minimum of 8+ years of experience. Demonstrated track record of successful analytical method development and product characterization for late stage protein therapeutic development. In-depth knowledge and extensive hands-on experience in developing a wide array of analytical protein characterization methods (e.g. HPLC-based methods, capillary electrophoresis, LC / MS peptide mapping, etc.). Prior experience with Phase III IND and BLA authoring considered a plus. Demonstrated ability to work effectively and collaboratively with other scientists on cross-functional projects teams. Excellent critical thinking, scientific problem-solving, and organizational skills. Excellent oral and written communication skills. Motivated, detail-oriented, scientifically driven individual with a creative approach to problem solving. Relocation funding is available for this role. The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The companys policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants . J-18808-Ljbffr Create a job alert for this search Principal Scientist • San Francisco, CA, United States #J-18808-Ljbffr Genentech

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